Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study (2024)

Madotto, F., Rezoagli, E., Pham, T., Schmidt, M., McNicholas, B., Protti, A., Panwar, R., Bellani, G., Fan, E., Van Haren, F., Brochard, L., Laffey, J. G., Pesenti, A., Brochard, L., Esteban, A., Gattinoni, L., Larsson, A., McAuley, D. F., Ranieri, M., ... Veljovic, M. (2020). Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study. Critical Care, 24(1), Article 125. https://doi.org/10.1186/s13054-020-2826-6

Madotto, Fabiana ; Rezoagli, Emanuele ; Pham, Tài et al. / Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study. In: Critical Care. 2020 ; Vol. 24, No. 1.

@article{b033d5cfb4724b56bd92cc8247b1c53a,

title = "Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study",

abstract = "Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov,",

keywords = "Acute respiratory distress syndrome, Hyperoxemia, Hyperoxia, Hypoxemia, Hypoxia, Invasive mechanical ventilation, Mortality, Oxygen therapy",

author = "Fabiana Madotto and Emanuele Rezoagli and T{\`a}i Pham and Marcello Schmidt and Bairbre McNicholas and Alessandro Protti and Raksh*t Panwar and Giacomo Bellani and Eddy Fan and {Van Haren}, Frank and Laurent Brochard and Laffey, {John G.} and Antonio Pesenti and Laurent Brochard and Andres Esteban and Luciano Gattinoni and Anders Larsson and McAuley, {Daniel F.} and Marco Ranieri and Gordon Rubenfeld and Thompson, {B. Taylor} and Hermann Wrigge and slu*tsky, {Arthur S.} and Fernando Rios and T. Sottiaux and P. Depuydt and Lora, {Fredy S.} and Azevedo, {Luciano Cesar} and Eddy Fan and Guillermo Bugedo and Haibo Qiu and Marcos Gonzalez and Juan Silesky and Vladimir Cerny and Jonas Nielsen and Manuel Jibaja and T{\`a}i Pham and Dimitrios Matamis and Ranero, {Jorge Luis} and Pravin Amin and Hashemian, {S. M.} and Kevin Clarkson and Kiyoyasu Kurahashi and Asisclo Villagomez and Zeggwagh, {Amine Ali} and Heunks, {Leo M.} and Laake, {Jon Henrik} and Palo, {Jose Emmanuel} and {Do Vale Fernandes}, Antero and Dorel Sandesc and Yaasen Arabi and Vesna Bumbasierevic and Nicolas Nin and Lorente, {Jose A.} and Lise Piquilloud and Fekri Abroug and Lia McNamee and Javier Hurtado and Ed Bajwa and Gabriel D{\'e}mpaire and Theresa, {Uhc Mother} and Hektor Sula and Lordian Nunci and Alma Cani and Villa Maria and Alan Zazu and Christian Dellera and Insaurralde, {Carolina S.} and Alejandro, {Risso V.} and Julio Daldin and Mauricio Vinzio and Fernandez, {Ruben O.} and Cardonnet, {Luis P.} and Bettini, {Lisandro R.} and Bisso, {Mariano Carboni} and Osman, {Emilio M.} and Setten, {Mariano G.} and Pablo Lovazzano and Javier Alvarez and Veronica Villar and Pozo, {Norberto C.} and Nicolas Grubissich and Plotnikow, {Gustavo A.} and Vasquez, {Daniela N.} and Santiago Ilutovich and Norberto Tiribelli and Ariel Chena and Pellegrini, {Carlos A.} and Saenz, {Mar{\'i}a G.} and Elisa Estenssoro and Matias Brizuela and Hernan Gianinetto and Gomez, {Pablo E.} and Cerrato, {Valeria I.} and Bezzi, {Marco G.} and Borello, {Silvina A.} and Loiacono, {Flavia A.} and Fernandez, {Adriana M.} and Serena Knowles and Claire Reynolds and Inskip, {Deborah M.} and Miller, {Jennene J.} and Jing Kong and Christina Whitehead and Shailesh Bihari and Aylin Seven and Amanda Krstevski and Rodgers, {Helen J.} and Millar, {Rebecca T.} and McKenna, {Toni E.} and Bailey, {Irene M.} and Hanlon, {Gabrielle C.} and Anders Aneman and Lynch, {Joan M.} and Raman Azad and John Neal and Woods, {Paul W.} and Roberts, {Brigit L.} and Kol, {Mark R.} and Wong, {Helen S.} and Riss, {Katharina C.} and Thomas Staudinger and Xavier Wittebole and Caroline Berghe and Bulpa, {Pierre A.} and Dive, {Alain M.} and Rik Verstraete and Herve Lebbinck and Pieter Depuydt and Joris Vermassen and Philippe Meersseman and Helga Ceunen and Rosa, {Jonas I.} and Beraldo, {Daniel O.} and Claudio Piras and Rampinelli, {Adenilton M.} and Nassar, {Antonio P.} and Sergio Mataloun and Marcelo Moock and Thompson, {Marlus M.} and Gon{\c c}alves, {Claudio H.} and Ant{\^o}nio, {Ana Carolina P.} and Aline Ascoli and Biondi, {Rodrigo S.} and Fontenele, {Danielle C.} and Danielle Nobrega and Sales, {Vanessa M.} and Suresh Shindhe and {Pg Hj Ismail}, {Dk Maizatul Aiman B.} and Francois Beloncle and Davies, {Kyle G.} and Rob Cirone and Venika Manoharan and Mehvish Ismail and Goligher, {Ewan C.} and Mandeep Jassal and Erin Nishikawa and Areej Javeed and Gerard Curley and Nuttapol Rittayamai and Matteo Parotto and Ferguson, {Niall D.} and Sangeeta Mehta and Jenny Knoll and Antoine Pronovost and Sergio Canestrini and Bruhn, {Alejandro R.} and Garcia, {Patricio H.} and Aliaga, {Felipe A.} and Far{\'i}as, {Pamela A.} and Yumha, {Jacob S.} and Ortiz, {Claudia A.} and Salas, {Javier E.} and Saez, {Alejandro A.} and Vega, {Luis D.} and Labarca, {Eduardo F.} and Martinez, {Felipe T.} and Carre{\~n}o, {Nicol{\'a}s G.} and Pilar Lora and Haitao Liu and Ling Liu and Rui Tang and Xiaoming Luo and Youzhong An and Huiying Zhao and Yan Gao and Zhe Zhai and Ye, {Zheng L.} and Wei Wang and Wenwen Li and Qingdong Li and Ruiqiang Zheng and Wenkui Yu and Juanhong Shen and Xinyu Li and Tao Yu and Weihua Lu and Wu, {Ya Q.} and Huang, {Xiao B.} and Zhenyang He and Yuanhua Lu and Hui Han and Fan Zhang and Renhua Sun and Wang, {Hua X.} and Qin, {Shu H.} and Zhu, {Bao H.} and Jun Zhao and Jian Liu and Bin Li and Liu, {Jing L.} and Zhou, {Fa C.} and Li, {Qiong J.} and Zhang, {Xing Y.} and Zhou Li-Xin and Qiang Xin-Hua and Liangyan Jiang and Gao, {Yuan N.} and Zhao, {Xian Y.} and Li, {Yuan Y.} and Li, {Xiao L.} and Chunting Wang and Qingchun Yao and Rongguo Yu and Kai Chen and Huanzhang Shao and Bingyu Qin and Huang, {Qing Q.} and Zhu, {Wei H.} and Hang, {Ai Y.} and Hua, {Ma X.} and Yimin Li and Yonghao Xu and Di, {Yu D.} and Ling, {Long L.} and Qin, {Tie H.} 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Doroth{\'e}e Carpentier and Zogheib, {Elie H.} and Herve Dupont and Sylvie Ricome and Santoli, {Francesco L.} and Besset, {Sebastien L.} and Philippe Michel and Bruno Gel{\'e}e and Danin, {Pierre Eric} and Bernard Goubaux and Crova, {Philippe J.} and Phan, {Nga T.} and Frantz Berkelmans and Badie, {Julio C.} and Romain Tapponnier and Josette Gally and Samy Khebbeb and Herbrecht, {Jean Etienne} and Francis Schneider and Declercq, {Pierre Louis M.} and Rigaud, {Jean Philippe} and Jacques Duranteau and Anatole Harrois and Russell Chabanne and Julien Marin and Charlene Bigot and Sandrine Thibault and Mohammed Ghazi and Messabi Boukhazna and Zein, {Salem Ould} and Richecoeur, {Jack R.} and Combaux, {Daniele M.} and Fabien Grelon and {Le Moal}, Charlene and Sauvadet, {Elise P.} and Adrien Robine and Virginie Lemiale and Danielle Reuter and Martin Dres and Alexandre Demoule and Dany Goldgran-Toledano and Loredana Baboi and Claude Gu{\'e}rin and Ralph Lohner and Jens Kra{\ss}ler and Susanne 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and Ferdinando Raimondi and Daniela Albiero and Giulia Crapelli and Eduardo Beck and Vincenzo Pota and Vincenzo Schiavone and Alexandre Molin and Fabio Tarantino and Giacomo Monti and Elena Frati and Lucia Mirabella and Gilda Cinnella and Tommaso Fossali and Riccardo Colombo and Pattarino, {Pierpaolo Terragni Ilaria} and Francesco Mojoli and Antonio Braschi and Borotto, {Erika E.} and Cracchiolo, {Andrea N.} and Palma, {Daniela M.} and Francesco Raponi and Giuseppe Foti and Vascotto, {Ettore R.} and Andrea Coppadoro and Luca Brazzi and Leda Floris and Iotti, {Giorgio A.} and Aaron Venti and Osamu Yamaguchi and Shunsuke Takagi and Maeyama, {Hiroki N.} and Eizo Watanabe and Yoshihiro Yamaji and Kazuyoshi Shimizu and Kyoko Shiozaki and Satoru Futami and Sekine Ryosuke and Koji Saito and Yoshinobu Kameyama and Keiko Ueno and Masayo Izawa and Nao Okuda and Hiroyuki Suzuki and Tomofumi Harasawa and Michitaka Nasu and Tadaaki Takada and Fumihito Ito and Shin-Nunomiya and Kohkichi Andoh and Kohei Kusumoto and Akira Hirata and Akihiro Takaba and Hiroyasu Kimura and Kansuke-Koyama and Ushio Higashijima and Hiroyuki Honda and Nobumasa Aoki and Hiroshi Imai and Yasuaki Ogino and Ichiko Mizuguchi and Kazuya Ichikado and Kenichi Nitta and Katsunori Mochizuki and Tomoaki Hashida and Hiroyuki Tanaka and Tomoyuki Nakamura and Daisuke Niimi and Takeshi Ueda and Yozo Kashiwa and Akinori Uchiyama and Olegs Sabelnikovs and Peteris Oss and Youssef Haddad and Liew, {Kong Y.} and {\~N}amendys-Silva, {Silvio A.} and Jarquin-Badiola, {Yves D.} and Sanchez-Hurtado, {Luis A.} and Gomez-Flores, {Saira S.} and Marin, {Maria C.} and Villagomez, {Asisclo J.} and Lemus, {Jordana S.} and Fierro, {Jonathan M.} and Cervantes, {Mavy Ramirez} and Mejia, {Francisco Javier Flores} and Dulce Dector and Dector, {Dulce M.} and Gonzalez, {Daniel R.} and Estrella, {Claudia R.} and Sanchez-Medina, {Jorge R.} and Alvaro Ramirez-Gutierrez and George, {Fernando G.} and Aguirre, {Janet S.} and Buensuseso, {Juan 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John} and Hagan, {Samantha J.} and Wise, {Matt P.} and Cole, {Jade M.} and MacFie, {Caroline C.} and Dowling, {Anna T.} and Nicol{\'a}s Nin and Edgardo Nu{\~n}ez and Gustavo Pittini and Ruben Rodriguez and Imperio, {Mar{\'i}a C.} and Cristina Santos and Fran{\c c}a, {Ana G.} and Alejandro Ebeid and Alberto Deicas and Carolina Serra and Aditya Uppalapati and Ghassan Kamel and Banner-Goodspeed, {Valerie M.} and Beitler, {Jeremy R.} and Mukkera, {Satyanarayana Reddy} and Shreedhar Kulkarni and Jarone Lee and Tomaz Mesar and Shinn, {John O.} and Dina Gomaa and Christopher Tainter and Yeatts, {Dale J.} and Jessica Warren and Lanspa, {Michael J.} and Miller, {Russel R.} and Grissom, {Colin K.} and Brown, {Samuel M.} and Bauer, {Philippe R.} and Gosselin, {Ryan J.} and Kitch, {Barrett T.} and Cohen, {Jason E.} and Beegle, {Scott H.} and Gueret, {Renaud M.} and Aiman Tulaimat and Shazia Choudry and William Stigler and Hitesh Batra and Huff, {Nidhi G.} and Lamb, {Keith D.} and Oetting, {Trevor W.} and Mohr, {Nicholas M.} and Claine Judy and Shigeki Saito and Kheir, {Fayez M.} and Fayez Kheir and Schlichting, {Adam B.} and Angela Delsing and Crouch, {Daniel R.} and Mary Elmasri and Dina Ismail and Dreyer, {Kyle R.} and Blakeman, {Thomas C.} and Baron, {Rebecca M.} and Grijalba, {Carolina Quintana} and Hou, {Peter C.} and Raghu Seethala and Imo Aisiku and Galen Henderson and Gyorgy Frendl and Hou, {Sen Kuang} and Owens, {Robert L.} and Ashley Schomer and Vesna Bumbasirevic and Bojan Jovanovic and Maja Surbatovic and Milic Veljovic",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",

year = "2020",

month = mar,

day = "31",

doi = "10.1186/s13054-020-2826-6",

language = "English",

volume = "24",

journal = "Critical Care",

issn = "1364-8535",

publisher = "BioMed Central Ltd.",

number = "1",

}

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study. / Madotto, Fabiana; Rezoagli, Emanuele; Pham, Tài et al.
In: Critical Care, Vol. 24, No. 1, 125, 31.03.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome

T2 - Insights from the LUNG SAFE study

AU - Madotto, Fabiana

AU - Rezoagli, Emanuele

AU - Pham, Tài

AU - Schmidt, Marcello

AU - McNicholas, Bairbre

AU - Protti, Alessandro

AU - Panwar, Raksh*t

AU - Bellani, Giacomo

AU - Fan, Eddy

AU - Van Haren, Frank

AU - Brochard, Laurent

AU - Laffey, John G.

AU - Pesenti, Antonio

AU - Brochard, Laurent

AU - Esteban, Andres

AU - Gattinoni, Luciano

AU - Larsson, Anders

AU - McAuley, Daniel F.

AU - Ranieri, Marco

AU - Rubenfeld, Gordon

AU - Thompson, B. Taylor

AU - Wrigge, Hermann

AU - slu*tsky, Arthur S.

AU - Rios, Fernando

AU - Sottiaux, T.

AU - Depuydt, P.

AU - Lora, Fredy S.

AU - Azevedo, Luciano Cesar

AU - Fan, Eddy

AU - Bugedo, Guillermo

AU - Qiu, Haibo

AU - Gonzalez, Marcos

AU - Silesky, Juan

AU - Cerny, Vladimir

AU - Nielsen, Jonas

AU - Jibaja, Manuel

AU - Pham, Tài

AU - Matamis, Dimitrios

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AU - Laake, Jon Henrik

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AU - Sandesc, Dorel

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AU - Nin, Nicolas

AU - Lorente, Jose A.

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AU - McNamee, Lia

AU - Hurtado, Javier

AU - Bajwa, Ed

AU - Démpaire, Gabriel

AU - Theresa, Uhc Mother

AU - Sula, Hektor

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AU - Cani, Alma

AU - Maria, Villa

AU - Zazu, Alan

AU - Dellera, Christian

AU - Insaurralde, Carolina S.

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AU - Daldin, Julio

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AU - Riss, Katharina C.

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AU - Rosa, Jonas I.

AU - Beraldo, Daniel O.

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AU - Liu, Ling

AU - Tang, Rui

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AU - Zhao, Huiying

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AU - Zhai, Zhe

AU - Ye, Zheng L.

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AU - Li, Wenwen

AU - Li, Qingdong

AU - Zheng, Ruiqiang

AU - Yu, Wenkui

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AU - Sun, Renhua

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AU - Zhao, Jun

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AU - Zhao, Xian Y.

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AU - Wang, Chunting

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AU - Llano, Miguel

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AU - Pelletier, Nicolas

AU - Mortaza, Satar

AU - Mercat, Alain

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AU - Daubin, Cédric

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AU - Biehler, Jerome

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AU - Roux, Damien

AU - Messika, Jonathan

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AU - Dangers, Laurence

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AU - Ghazi, Mohammed

AU - Boukhazna, Messabi

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AU - Le Moal, Charlene

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AU - Goldgran-Toledano, Dany

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AU - Guérin, Claude

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AU - Kraßler, Jens

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AU - Zacharowski, Kai D.

AU - Meybohm, Patrick

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AU - Papanikolaou, Metaxia N.

AU - Papavasilopoulou, Theonymfi G.

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AU - Gurjar, Mohan

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AU - Unnikrishnan, Ramesh

AU - Dixit, Subhal B.

AU - Rhayakar, Rachana V.

AU - Ramakrishnan, Nagarajan

AU - Bhardwaj, Vallish K.

AU - Mahto, Heera L.

AU - Sagar, Sudha V.

AU - Palaniswamy, Vijayanand

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AU - Palmese, Salvatore

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AU - Pecci, Elisabetta

AU - Botteri, Marco

AU - Savioli, Monica

AU - Protti, Alessandro

AU - Mattei, Alessia

AU - Schiavoni, Lorenzo

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AU - Giarratano, Antonino

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AU - Biscione, Roberto R.

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AU - Raimondi, Ferdinando

AU - Albiero, Daniela

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AU - Beck, Eduardo

AU - Pota, Vincenzo

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AU - Molin, Alexandre

AU - Tarantino, Fabio

AU - Monti, Giacomo

AU - Frati, Elena

AU - Mirabella, Lucia

AU - Cinnella, Gilda

AU - Fossali, Tommaso

AU - Colombo, Riccardo

AU - Pattarino, Pierpaolo Terragni Ilaria

AU - Mojoli, Francesco

AU - Braschi, Antonio

AU - Borotto, Erika E.

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AU - Raponi, Francesco

AU - Foti, Giuseppe

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AU - Maeyama, Hiroki N.

AU - Watanabe, Eizo

AU - Yamaji, Yoshihiro

AU - Shimizu, Kazuyoshi

AU - Shiozaki, Kyoko

AU - Futami, Satoru

AU - Ryosuke, Sekine

AU - Saito, Koji

AU - Kameyama, Yoshinobu

AU - Ueno, Keiko

AU - Izawa, Masayo

AU - Okuda, Nao

AU - Suzuki, Hiroyuki

AU - Harasawa, Tomofumi

AU - Nasu, Michitaka

AU - Takada, Tadaaki

AU - Ito, Fumihito

AU - Shin-Nunomiya,

AU - Andoh, Kohkichi

AU - Kusumoto, Kohei

AU - Hirata, Akira

AU - Takaba, Akihiro

AU - Kimura, Hiroyasu

AU - Kansuke-Koyama,

AU - Higashijima, Ushio

AU - Honda, Hiroyuki

AU - Aoki, Nobumasa

AU - Imai, Hiroshi

AU - Ogino, Yasuaki

AU - Mizuguchi, Ichiko

AU - Ichikado, Kazuya

AU - Nitta, Kenichi

AU - Mochizuki, Katsunori

AU - Hashida, Tomoaki

AU - Tanaka, Hiroyuki

AU - Nakamura, Tomoyuki

AU - Niimi, Daisuke

AU - Ueda, Takeshi

AU - Kashiwa, Yozo

AU - Uchiyama, Akinori

AU - Sabelnikovs, Olegs

AU - Oss, Peteris

AU - Haddad, Youssef

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AU - Albarrak, Mohamad M.

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AU - Esteve, Francisco

AU - Rialp, Gemma

AU - Forteza, Catalina

AU - De Haro, Candelaria

AU - Artigas, Antonio

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AU - De Cima-Iglesias, Sara

AU - Seoane-Quiroga, Leticia

AU - Ceniceros-Barros, Alexandra

AU - Ruiz-Aguilar, Antonio L.

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AU - Soler, Juan Alfonso

AU - Del Carmen Lorente, Maria

AU - Hermosa, Cecilia

AU - Gordo, Federico

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AU - Perez, Manuel P.

AU - Perez, Cesar P.

AU - Allue, Raquel Montoiro

AU - Roche-Campo, Ferran

AU - Ibañez-Santacruz, Marcos

AU - Susana-Temprano,

AU - De Pablo, Raul

AU - Gómez, Pilar Ricart Aroa

AU - Ruiz, Silvia Rodriguez

AU - Moles, Silvia Iglesias

AU - Jurado, Mª Teresa

AU - Arizmendi, Alfons

AU - Piacentini, Enrique A.

AU - Franco, Nieves

AU - Honrubia, Teresa

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AU - Losada, Elena Perez

AU - Javier-Blanco,

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AU - Navarro, Gonzalo

AU - Cereijo, Enrique

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AU - Sanchez, Roberto Jimenez

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AU - Yuste, Luis J.

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AU - Curto, Elena Gallego

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AU - Rodriguez, Lucia L.

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AU - González-Salamanca, Ángela

AU - Jimenez, Antonio G.

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AU - Lopez, Esther Bermejo

AU - Llinares Moya, David D.

AU - Tallet Alfonso, Alec A.

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AU - Cesar, Palazon Sanchez

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AU - Recio, Noelia N.

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AU - Schiöler, Fredrik

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AU - Hedlund, Lars

AU - Helleberg, Johan

AU - Eriksson, Karin E.

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AU - Larsson, Niklas

AU - Nygren, Ingela

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AU - Zender, Hervé O.

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AU - Elatrous, Souheil

AU - Bouchoucha, Slaheddine

AU - Chouchene, Imed

AU - Ouanes, Islem

AU - Souissi, Asma Ben

AU - Kamoun, Salma

AU - Demirkiran, Oktay

AU - Aker, Mustafa

AU - Erbabacan, Emre

AU - Ceylan, Ilkay

AU - Girgin, Nermin Kelebek

AU - Ozcelik, Menekse

AU - Ünal, Necmettin

AU - Meco, Basak Ceyda

AU - Akyol, Onat O.

AU - Derman, Suleyman S.

AU - Kennedy, Barry

AU - Parhar, Ken

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AU - Hopkins, Phil

AU - Mellis, Clare

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AU - Bhowmick, Kaushik

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AU - Bramall, Jon

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AU - Toth-Tarsoly, Piroska

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AU - Welters, Ingeborg D.

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AU - Battle, Ceri E.

AU - Pillai, Suresh

AU - Kajtor, Istvan

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AU - Nin, Nicolás

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AU - Rodriguez, Ruben

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AU - França, Ana G.

AU - Ebeid, Alejandro

AU - Deicas, Alberto

AU - Serra, Carolina

AU - Uppalapati, Aditya

AU - Kamel, Ghassan

AU - Banner-Goodspeed, Valerie M.

AU - Beitler, Jeremy R.

AU - Mukkera, Satyanarayana Reddy

AU - Kulkarni, Shreedhar

AU - Lee, Jarone

AU - Mesar, Tomaz

AU - Shinn, John O.

AU - Gomaa, Dina

AU - Tainter, Christopher

AU - Yeatts, Dale J.

AU - Warren, Jessica

AU - Lanspa, Michael J.

AU - Miller, Russel R.

AU - Grissom, Colin K.

AU - Brown, Samuel M.

AU - Bauer, Philippe R.

AU - Gosselin, Ryan J.

AU - Kitch, Barrett T.

AU - Cohen, Jason E.

AU - Beegle, Scott H.

AU - Gueret, Renaud M.

AU - Tulaimat, Aiman

AU - Choudry, Shazia

AU - Stigler, William

AU - Batra, Hitesh

AU - Huff, Nidhi G.

AU - Lamb, Keith D.

AU - Oetting, Trevor W.

AU - Mohr, Nicholas M.

AU - Judy, Claine

AU - Saito, Shigeki

AU - Kheir, Fayez M.

AU - Kheir, Fayez

AU - Schlichting, Adam B.

AU - Delsing, Angela

AU - Crouch, Daniel R.

AU - Elmasri, Mary

AU - Ismail, Dina

AU - Dreyer, Kyle R.

AU - Blakeman, Thomas C.

AU - Baron, Rebecca M.

AU - Grijalba, Carolina Quintana

AU - Hou, Peter C.

AU - Seethala, Raghu

AU - Aisiku, Imo

AU - Henderson, Galen

AU - Frendl, Gyorgy

AU - Hou, Sen Kuang

AU - Owens, Robert L.

AU - Schomer, Ashley

AU - Bumbasirevic, Vesna

AU - Jovanovic, Bojan

AU - Surbatovic, Maja

AU - Veljovic, Milic

N1 - Publisher Copyright:© 2020 The Author(s).

PY - 2020/3/31

Y1 - 2020/3/31

N2 - Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov,

AB - Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov,

KW - Acute respiratory distress syndrome

KW - Hyperoxemia

KW - Hyperoxia

KW - Hypoxemia

KW - Hypoxia

KW - Invasive mechanical ventilation

KW - Mortality

KW - Oxygen therapy

UR - http://www.scopus.com/inward/record.url?scp=85082749073&partnerID=8YFLogxK

U2 - 10.1186/s13054-020-2826-6

DO - 10.1186/s13054-020-2826-6

M3 - Article

SN - 1364-8535

VL - 24

JO - Critical Care

JF - Critical Care

IS - 1

M1 - 125

ER -

Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A et al. Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study. Critical Care. 2020 Mar 31;24(1):125. doi: 10.1186/s13054-020-2826-6